产品名称

英文名称：GSK-690693

同义词

937174-76-0、GSK690693、GSK-690693、GSK 690693、(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol、4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo

产品性质

CAS编号：937174-76-0

分子式：C21H27N7O3

分子量：425.48

MDL号：MFCD14105605

PubChem编号：16725726

英文别名：937174-76-0|GSK690693|GSK-690693|GSK 690693|(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol|4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo

规格或纯度：≥98%

英文名称：GSK-690693

生化机理：GSK-690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). GSK-690693 also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). GSK-690693 displays antiproliferative and apoptotic effects in tumor cell lines.Novel ATP-competitive pan-Akt kinase inhibitor (IC 50 values are 2, 13 and 9 nM for\xa0Akt1, 2 and 3 respectively). Also exhibits some inhibition\xa0of AMPK, PKA and PAK and PKC isoforms (IC 50 < 100 nM). Displays antiproliferative and apoptotic effects i

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Novel ATP-competitive pan-Akt kinase inhibitor.GSK690693 has been used in western blotting and immunoprecipitations.Novel ATP-competitive pan-Akt kinase inhibitor.GSK690693 has been used in western blotting and immunoprecipitations.

ALogP：0.3

IUPAC Name：4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3S)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol

INCHI：InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

InChi Key：KGPGFQWBCSZGEL-ZDUSSCGKSA-N

Canonical SMILES：CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N

Isomeric SMILES：CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N

WGK Germany：3

PubChem CID：16725726

CAS Registry No.：937174-76-0

DiscoveRx TREEspot：GSK-690693|

ChEMBL Ligand：CHEMBL494089

RCSB PDB Ligand：G93

溶解性：Soluble in DMSO to 20 mM and in ethanol to 60 mM

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

产品包装