产品名称

英文名称：Plinabulin (NPI-2358)

同义词

Plinabulin、714272-27-2、NPI-2358、Plinabulin (NPI-2358)、Plinabulin(NPI-2358)、NPI-2358 (Plinabulin)、NPI 2358、(3z,6z)-3-Benzylidene-6-[(5-Tert-Butyl-1h-Imidazol-4-Yl)methylidene]piperazine-2,5-Dione、986FY7F8XR、NPI2358、(3E,6E)-3-Benzylidene-6-[(5-tert-butyl-1H

产品性质

CAS编号：714272-27-2

分子式：C19H20N4O2

分子量：336.39

PubChem编号：9949641

英文别名：Plinabulin|714272-27-2|NPI-2358|Plinabulin (NPI-2358)|Plinabulin(NPI-2358)|NPI-2358 (Plinabulin)|NPI 2358|(3z,6z)-3-Benzylidene-6-[(5-Tert-Butyl-1h-Imidazol-4-Yl)methylidene]piperazine-2,5-Dione|986FY7F8XR|NPI2358|(3E,6E)-3-Benzylidene-6-[(5-tert-butyl-1H

规格或纯度：≥97%

英文名称：Plinabulin (NPI-2358)

生化机理：NPI-2358 (Plinabulin) is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM against HT-29 cells. NPI-2358 binds to the colchicine-binding site of tubulin. NPI-2358 has potent in-vitro anti-tumor activity against various human tumor cell lines and maintains activity against tumor cell lines with various MDR profiles.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Plinabulin (NPI-2358)是一种vascular disrupting agents(VDA)（血管阻断剂），作用于肿瘤细胞，影响微管蛋白解聚，IC50为9.8~18 nM。Phase 1/2。Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.

ALogP：2.8

IUPAC Name：(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione

INCHI：InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9-,15-10-

InChi Key：UNRCMCRRFYFGFX-TYPNBTCFSA-N

Canonical SMILES：CC(C)(C)C1=C(N=CN1)C=C2C(=O)NC(=CC3=CC=CC=C3)C(=O)N2

Isomeric SMILES：CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2

PubChem CID：9949641

溶解性：DMSO 67 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装