产品名称

英文名称：SB742457

同义词

Intepirdine、607742-69-8、SB-742457、SB742457、GSK-742457、SB 742457、3-(PHENYLSULFONYL)-8-(PIPERAZIN-1-YL)QUINOLINE、RVT-101、Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-、3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline、GSK 742457、2IOB2M82HY、CHEMBL1083390、3-(ben

产品性质

CAS编号：607742-69-8

分子式：C19H19N3O2S

分子量：353.44

PubChem编号：11256720

英文别名：Intepirdine|607742-69-8|SB-742457|SB742457|GSK-742457|SB 742457|3-(PHENYLSULFONYL)-8-(PIPERAZIN-1-YL)QUINOLINE|RVT-101|Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-|3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline|GSK 742457|2IOB2M82HY|CHEMBL1083390|3-(ben

规格或纯度：≥97%

英文名称：SB742457

生化机理：SB-742457, a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. SB-742457 is generally safe and well tolerated and may be efficacious in Alzheimer disease.Potent (pKi = 9.63) and highly selective 5-HT6 antagonist. Greater thsan 100-fold selective against other receptors. Reverses learning impairment in animal models.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.

ALogP：2.5

IUPAC Name：3-(benzenesulfonyl)-8-piperazin-1-ylquinoline

INCHI：InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2

InChi Key：JJZFWROHYSMCMU-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4

Isomeric SMILES：C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4

PubChem CID：11256720

CAS Registry No.：607742-69-8

ChEMBL Ligand：CHEMBL1083390

BindingDB Ligand：50318633

GPCRdb Ligand：intepirdine

溶解性：DMSO 78 mg/mL Water <1 mg/mL Ethanol 2 mg/mL

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

产品包装