产品名称

英文名称：PHA-848125

同义词

Milciclib、PHA-848125、802539-81-7、PHA 848125、Milciclib [INN]、Milciclib (PHA-848125)、UNII-688000M8S8、PHA848125、4,5-dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide、N,1,4,4-tetramethyl-8-((4-

产品性质

CAS编号：802539-81-7

分子式：C25H32N8O

分子量：460.57

PubChem编号：16718576

英文别名：Milciclib|PHA-848125|802539-81-7|PHA 848125|Milciclib [INN]|Milciclib (PHA-848125)|UNII-688000M8S8|PHA848125|4,5-dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide|N,1,4,4-tetramethyl-8-((4-

规格或纯度：≥98%

英文名称：PHA-848125

生化机理：PHA-848125 is an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity.Potent, ATP-competitive CDK2/cyclin A (IC 50 = 45 nM) and Trk A inhibitor (IC 50 =\xa053 nM). Also inhibits, although with lower potency, the activities of CDK7/cyclin H, CDK4/cyclin D1, CDK5/p35, as well as CDK2/cyclin E and CDK1/cyclin B (IC 50 values\x

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

ALogP：2.8

IUPAC Name：N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5H-pyrazolo[4,3-h]quinazoline-3-carboxamide

INCHI：InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)

InChi Key：RXZMYLDMFYNEIM-UHFFFAOYSA-N

Canonical SMILES：CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C

Isomeric SMILES：CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C

PubChem CID：16718576

CAS Registry No.：802539-81-7

ChEMBL Ligand：CHEMBL564829

RCSB PDB Ligand：P48

溶解性：DMSO 92 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装