产品名称

英文名称：AZD1480

同义词

AZD1480、935666-88-9、AZD-1480、(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine、AZD 1480、UNII-KL2Z2TLF01、C14H14ClFN8、KL2Z2TLF01、CHEMBL1231124、5-Chloro-N2-[(1s)-1-(5-Fluoropyrimidin-2-Yl)ethyl]-N4-(5-Methy

产品性质

CAS编号：935666-88-9

分子式：C14H14ClFN8

分子量：348.77

PubChem编号：16659841

英文别名：AZD1480|935666-88-9|AZD-1480|(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine|AZD 1480|UNII-KL2Z2TLF01|C14H14ClFN8|KL2Z2TLF01|CHEMBL1231124|5-Chloro-N2-[(1s)-1-(5-Fluoropyrimidin-2-Yl)ethyl]-N4-(5-Methy

规格或纯度：≥98%

英文名称：AZD1480

生化机理：AZD1480 demonstrated significant immunoregulatory effects by downregulating T-helper 2 cytokines and chemokines, including IL-13 and thymus- and activation-regulated chemokine, and the surface expression of the immunosuppressive programmed death ligands 1 and 2. Higher concentrations of AZD1480 (5μ) induced G2/M arrest and cell death by inhibiting Aurora kinases.Novel, potent and selective small-molecule JAK2 inhibitor (IC 50 < 3 nM). \xa0It can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. Also demonstrates >50-fold selectivity for JAK2 over JAK3

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：AZD1480是ATP竞争性JAK2抑制剂，IC50为0.26 nM，对JAK1抑制性较弱。An inhibitor of JAK2AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.

ALogP：2.4

PubChem SID：488199394

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488199394

IUPAC Name：5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

INCHI：InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1

InChi Key：PDOQBOJDRPLBQU-QMMMGPOBSA-N

Canonical SMILES：CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F

Isomeric SMILES：CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F

PubChem CID：16659841

ChEMBL Ligand：CHEMBL1231124

CAS Registry No.：935666-88-9

RCSB PDB Ligand：AZ5

溶解性：DMSO ≥68mg/mL Water <1.2mg/mL Ethanol ≥4.7mg/mL

密度：1.5

折光率：1.7

沸点：~575.2 °C at 760 mmHg

熔点：213.39°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P260,P270,P330,P203,P301+P316,P318,P319

产品包装