产品名称

英文名称：Sotrastaurin

同义词

Sotrastaurin、425637-18-9、AEB071、Sotrastaurin (AEB071)、AEB-071、3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione、3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione、NVP-AEB071、CHEBI90531、7I27

产品性质

CAS编号：425637-18-9

分子式：C25H22N6O2

分子量：438.49

PubChem编号：10296883

英文别名：Sotrastaurin|425637-18-9|AEB071|Sotrastaurin (AEB071)|AEB-071|3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione|3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione|NVP-AEB071|CHEBI90531|7I27

规格或纯度：98%

英文名称：Sotrastaurin

生化机理：Sotrastaurin, a first-in-class protein kinase C (PKC) inhibitor, is aiming to become the first oral treatment that inhibits T-cell activation since the introduction of calcineurin inhibitors. T-cell activation is an early step in autoimmune diseases such as psoriasis and is also essential for the rejection of transplanted organs. Sotrastaurin blocks a pathway critical to T-cell activation and has shown promise in organ transplantation as well as in autoimmune disorders. Sotrastaurin is developed for the potential treatment of psoriatic skin lesions and graft rejection.Potent, selective pan-PKC inhibitor (K i values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM\xa0 for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay) . Prevents the production of various cytokines by activated T cells, macrophages, and keratinocyt

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：2.6

IUPAC Name：3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

INCHI：InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)

InChi Key：OAVGBZOFDPFGPJ-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

Isomeric SMILES：CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

PubChem CID：10296883

CAS Registry No.：425637-18-9

ChEMBL Ligand：CHEMBL565612

RCSB PDB Ligand：LW4

溶解性：DMSO 87 mg/mL Water <1 mg/mL Ethanol 2 mg/mL

产品包装