产品名称

英文名称：Thiazovivin

同义词

Thiazovivin、1226056-71-8、N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide、Thiazovivin (GMP)、N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide、N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide、N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-4、N-苄基-2-(嘧啶-4-基氨基)噻唑-4-甲酰胺

产品性质

CAS编号：1226056-71-8

分子式：C15H13N5OS

分子量：311.36

PubChem编号：46209426

别名：N-苄基-2-(嘧啶-4-基氨基)噻唑-4-甲酰胺

英文别名：Thiazovivin|1226056-71-8|N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide|Thiazovivin (GMP)|N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide|N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide|N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-4

规格或纯度：≥99%

英文名称：Thiazovivin

生化机理：Thiazovivin is a compound which dramatically improves the survival of hESCs upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901, thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method.Thiazovivin is useful for reprogramming human somatic cells.Rho kinase inhibitor. Thiazovivin solution. Reverses Ang II-induced MYPT1 and MLC phosphorylation. Enhances fibroblast reprogramming efficiency during pluripotent stem cell formation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Thiazovivin是一种新型ROCK抑制剂，无细胞试验中IC50为0.5 μM，在单细胞分离后，促进人胚胎干细胞（hESC）的存活。Thiazovivin is a new type of ROCK inhibitor with an IC50 of 0.5 μM in a cell-free assay, which promotes the survival of human embryonic stem cells (hESC) after single cell isolation.

IUPAC Name：N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide

INCHI：InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)

InChi Key：DOBKQCZBPPCLEG-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3

Isomeric SMILES：C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3

WGK Germany：3

PubChem CID：46209426

溶解性：DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装