产品名称

英文名称：WYE-354

同义词

WYE-354、1062169-56-5、methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate、WYE354、WYE 354、methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine

产品性质

CAS编号：1062169-56-5

分子式：C24H29N7O5

分子量：495.54

PubChem编号：44219749

英文别名：WYE-354|1062169-56-5|methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate|WYE354|WYE 354|methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine

规格或纯度：≥98%

英文名称：WYE-354

生化机理：WYE-354 is an inhibitor of several PI3Ks at micromolar levels. WYE-354 is an effective inhibitor of both mTORC1 and mTORC2 in HEK293 cells. WYE-354 significantly blocks mTOR signaling and Akt activation in U87MG and MDA361 cells. WYE-354 is a potent inhibitor of proliferation in tumor cell lines including MDA-MB-361, MDA-MB-231, MDA-MB-468, LNCap, A498, and HCT116. WYE-354 induces apoptosis which is accompanied by G1 cell cycle arrest and caspases activation. WYE-354 inhibits both mTORC1 and mTORC2 signaling, as revealed by dephosphorylation of S6 ribosomal protein and Akt, respectively, in endothelial HUVEC cells. WYE-354 activates mitogen-activated protein kinase (MAPK) signaling, which may be due to its inhibition of mTORC1.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：WYE-354是ATP竞争性mTOR抑制剂，IC50为5 nM，能阻断mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473)，比对PI3Kα和PI3Kγ的抑制性强100倍和500倍。A potent, specific, and ATP-competitive inhibitor to mTOR with IC50 of 5 nMWYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).A potent, specific, and ATP-competitive inhibitor to mTOR with IC50 of 5 nM

IUPAC Name：methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

INCHI：InChI=1S/C24H29N7O5/c1-34-23(32)26-17-5-3-16(4-6-17)20-27-21(29-11-13-36-14-12-29)19-15-25-31(22(19)28-20)18-7-9-30(10-8-18)24(33)35-2/h3-6,15,18H,7-14H2,1-2H3,(H,26,32)

InChi Key：IMXHGCRIEAKIBU-UHFFFAOYSA-N

Canonical SMILES：COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

Isomeric SMILES：COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

PubChem CID：44219749

ChEMBL Ligand：CHEMBL561708

BindingDB Ligand：35587

CAS Registry No.：1062169-56-5

溶解性：DMSO ≥96mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

密度：1.5

折光率：~1.69

沸点：~594.2 °C at 760 mmHg

产品包装