产品名称

英文名称：PP242

同义词

PP242、1092351-67-1、TORKinib、PP-242、PP 242、2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol、Torkinib (PP242)、2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol、H5669VNZ7V、DTXSID5048685、CHEBI90679、2-(4-Amino-

产品性质

CAS编号：1092351-67-1

分子式：C16H16N6O

分子量：308.34

PubChem编号：135565635

英文别名：PP242|1092351-67-1|TORKinib|PP-242|PP 242|2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol|Torkinib (PP242)|2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol|H5669VNZ7V|DTXSID5048685|CHEBI90679|2-(4-Amino-

规格或纯度：≥98%

英文名称：PP242

生化机理：PP242 has been shown to be a an ATP-competitive mTORC1/mTORC2 (FRAP) inhibitor (IC50 = 8 nM). PP242 is the first selective inhibitor that targets the ATP domain of FRAP. This compound shows selectivity for FRAP over other PI 3K family kinases (IC50 values are 0.102, 0.408, 1.27, 1.96 and 2.2 μM for p110γ, DNA-PK, p110δ, p110α and p110β respectively). Furthermore, PP242 hydrate inhibits both S6K and 4EBP1 phosphorylation this activity displays an overall decrease in cap-dependent protein translation.Potent, selective and ATP-competitive mTOR inhibitor (IC 50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC 50 values are 0.1 (p110γ), 0.41 (DNA-PK)

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Torkinib (PP242)是一种选择性的mTOR抑制剂，IC50为8 nM；靶向作用于mTOR复合体，作用于mTOR比作用于PI3Kδ或PI3Kα/β/γ选择性分别高10倍多和100倍。A selective FRAP inhibitorTorkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively.A selective FRAP inhibitor

IUPAC Name：2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

INCHI：InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)

InChi Key：MFAQYJIYDMLAIM-UHFFFAOYSA-N

Canonical SMILES：CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(N3)C=CC(=C4)O)N

Isomeric SMILES：CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(N3)C=CC(=C4)O)N

PubChem CID：135565635

CAS Registry No.：1092351-67-1

DiscoveRx TREEspot：PP-242|

ChEMBL Ligand：CHEMBL1241674

RCSB PDB Ligand：P2X

溶解性：Soluble in DMSO (>10 mg/mL)

产品包装