产品名称

英文名称：RAF265 (CHIR-265)

同义词

RAF265、927880-90-8、CHIR-265、RAF-265、RAF 265、RAF265(CHIR-265)、RAF265 (CHIR-265)、CHIR 265、1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine、1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-

产品性质

CAS编号：927880-90-8

分子式：C24H16F6N6O

分子量：518.43

PubChem编号：11656518

英文别名：RAF265|927880-90-8|CHIR-265|RAF-265|RAF 265|RAF265(CHIR-265)|RAF265 (CHIR-265)|CHIR 265|1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine|1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-

规格或纯度：≥98%

英文名称：RAF265 (CHIR-265)

生化机理：Raf激酶和VEGFR-2抑制剂。抑制c-Raf，野生型B-Raf和突变B-Raf（V600E）。在某些黑色素瘤细胞系中具有细胞毒性。蛋白激酶D3抑制作用增强效果，防止MAPK信号传导重新激活并增加胱天蛋白酶活性。口服具有生物活性。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：RAF265 (CHIR-265)是一种高度选择性的B-Raf和VEGFR2抑制剂，IC50为3-60 nM，也抑制VEGFR2磷酸化， EC50为30 nM，Phase 2。An orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2.RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.An orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2.

ALogP：5.4

PubChem SID：488197644

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488197644

IUPAC Name：1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine

INCHI：InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)

InChi Key：YABJJWZLRMPFSI-UHFFFAOYSA-N

Canonical SMILES：CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

Isomeric SMILES：CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

PubChem CID：11656518

CAS Registry No.：927880-90-8

DiscoveRx TREEspot：A-674563|CHIR-265/RAF-265|

ChEMBL Ligand：CHEMBL558752

RCSB PDB Ligand：55J

溶解性：溶于DMSO, 最高浓度 (mg/mL) 51.84, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 10.37, 最高浓度(mM) 20

产品包装