产品名称

英文名称：CP-466722

同义词

1080622-86-1、CP-466722、CP466722、1-(6,7-dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine、CP 466722、2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine、CHEMBL2143829、HMS3265A20、GTPL9359、SCHEMBL15639218、CHEBI91330、DTXSID

产品性质

CAS编号：1080622-86-1

分子式：C17H15N7O2

分子量：349.35

PubChem编号：44551660

英文别名：1080622-86-1|CP-466722|CP466722|1-(6,7-dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine|CP 466722|2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine|CHEMBL2143829|HMS3265A20|GTPL9359|SCHEMBL15639218|CHEBI91330|DTXSID

规格或纯度：≥98%

英文名称：CP-466722

生化机理：CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase. The compound CP466722 disrupts ATM-dependent checkpoint cell cylce events, and reverses ATM-dependent substrate phosphorylation and downstream signaling events following exposure to ionizing radiation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍CP-466722是一种有效的，可逆的ATM抑制剂，不影响ATR，且抑制PI3K或PIKK家族成员。CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

IUPAC Name：2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine

INCHI：InChI=1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23)

InChi Key：ILBRKJBKDGCSCB-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)N3C(=NC(=N3)C4=CC=CC=N4)N)OC

Isomeric SMILES：COC1=C(C=C2C(=C1)C(=NC=N2)N3C(=NC(=N3)C4=CC=CC=N4)N)OC

WGK Germany：3

PubChem CID：44551660

CAS Registry No.：1080622-86-1

ChEMBL Ligand：CHEMBL2143829

溶解性：DMSO 0.28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装