产品名称

英文名称：Pimasertib (AS-703026)

同义词

Pimasertib、1236699-92-5、AS703026、AS-703026、Pimasertib (AS-703026)、AS 703026、MSC1936369B、(S)-N-(2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylamino)isonicotinamide、1204531-26-9、MSC-1936369、6ON9RK82AL、MSC1936369A、(S)-N-(2,3-dihydroxypropyl)-3-((2-fluoro-4-io

产品性质

CAS编号：1236699-92-5

分子式：C15H15FIN3O3

分子量：431.2

PubChem编号：44187362

英文别名：Pimasertib|1236699-92-5|AS703026|AS-703026|Pimasertib (AS-703026)|AS 703026|MSC1936369B|(S)-N-(2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylamino)isonicotinamide|1204531-26-9|MSC-1936369|6ON9RK82AL|MSC1936369A|(S)-N-(2,3-dihydroxypropyl)-3-((2-fluoro-4-io

规格或纯度：≥98%

英文名称：Pimasertib (AS-703026)

生化机理：AS703026 is a highly selective and potent noncompetitive inhibitor of MEK1 and MEK2 (IC50 = 5-11 nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Pimasertib (AS-703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.A potent inhibitor of MEK1 and MEK2.Pimasertib (AS-703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.A potent inhibitor of MEK1 and MEK2.

IUPAC Name：N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide

INCHI：InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1

InChi Key：VIUAUNHCRHHYNE-JTQLQIEISA-N

Canonical SMILES：C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O

Isomeric SMILES：C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O

PubChem CID：44187362

CAS Registry No.：1236699-92-5

ChEMBL Ligand：CHEMBL2107832

Reactome Reaction：R-HSA-9657606

Reactome Drug：R-ALL-9657523

RCSB PDB Ligand：QOA

溶解性：DMSO ≥83mg/mL Water <1.2mg/mL Ethanol ≥2.6mg/mL

产品包装