产品名称

英文名称：Voreloxin

同义词

Voreloxin、vosaroxin、175414-77-4、SNS-595、AG-7352、AG 7352、SPC-595、Vosaroxin (USAN)、Vosaroxin [USAN]、K6A90IIZ19、7-((3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid、Quinprezo、174726-60-4

产品性质

CAS编号：175414-77-4

分子式：C18H19N5O4S

分子量：401.44

PubChem编号：9952884

英文别名：Voreloxin|vosaroxin|175414-77-4|SNS-595|AG-7352|AG 7352|SPC-595|Vosaroxin (USAN)|Vosaroxin [USAN]|K6A90IIZ19|7-((3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid|Quinprezo|174726-60-4|

英文名称：Voreloxin

生化机理：Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects it does not generate reactive oxygen species, as do anthracyclines, reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrμg resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Voreloxin (SNS-595; Vosaroxin; AG 7352) 是一种新创的拓扑异构酶 II (topoisomerase II) 抑制剂，能够诱导 DNA 双链断裂，阻滞 G2 期，最终细胞凋亡。

IUPAC Name：7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid

INCHI：InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1

InChi Key：XZAFZXJXZHRNAQ-STQMWFEESA-N

Canonical SMILES：CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O

Isomeric SMILES：CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O

PubChem CID：9952884

溶解性：insoluble in H2O; insoluble in EtOH; insoluble in DMSO

产品包装