产品名称

英文名称：AZD4547

同义词

AZD4547、1035270-39-3、AZD-4547、AZD 4547、N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide、2167OG1EKJ、CHEBI63453、rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]ben

产品性质

CAS编号：1035270-39-3

分子式：C26H33N5O3

分子量：463.57

PubChem编号：51039095

英文别名：AZD4547|1035270-39-3|AZD-4547|AZD 4547|N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide|2167OG1EKJ|CHEBI63453|rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]ben

规格或纯度：≥99%

英文名称：AZD4547

生化机理：AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3. AZD4547 treatment potently inhibits FGFR and MAPK phosphorylation in tumor cell lines in a dose-dependent manner.Novel, selective\xa0inhibitor\xa0of the FGFR1, 2, and 3 tyrosine kinases. Binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, thus resulting in the inhibition of tumor cell proliferation and tumor c

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：AZD4547是一种新型选择性的FGFR抑制剂，靶向作用于FGFR1/2/3，IC50为0.2 nM/2.5 nM/1.8 nM，对FGFR4， VEGFR2(KDR)具有微弱的作用活性，对IGFR， CDK2和p38几乎没有作用活性。Phase 2/3。A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3.AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3.

IUPAC Name：N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide

INCHI：InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+

InChi Key：VRQMAABPASPXMW-HDICACEKSA-N

Canonical SMILES：CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

Isomeric SMILES：C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

PubChem CID：51039095

CAS Registry No.：1035270-39-3

ChEBI：CHEBI63453

RCSB PDB Ligand：66T

Reactome Reaction：R-HSA-2077420, R-HSA-2077424, R-HSA-2023462, R-HSA-2029992

Reactome Drug：R-ALL-2038886

溶解性：DMSO 92 mg/mL (198.45 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM);

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH302 Harmful if swallowedH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P321,P405,P501,P264,P260,P270,P330,P301+P316,P301+P317,P319

产品包装