产品名称

英文名称：INK 128 (MLN0128)

同义词

Sapanisertib、1224844-38-5、INK-128、MLN0128、INK 128、INK128、TAK-228、MLN-0128、5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine、INK 128 (MLN0128)、Sapanisertib (MLN0128)、UNII-JGH0DF1U03、JGH0DF1U03、CB-228、3-(2-Amino-5-benzoxazolyl)-

产品性质

CAS编号：1224844-38-5

分子式：C15H15N7O

分子量：309.33

PubChem编号：45375953

英文别名：Sapanisertib|1224844-38-5|INK-128|MLN0128|INK 128|INK128|TAK-228|MLN-0128|5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine|INK 128 (MLN0128)|Sapanisertib (MLN0128)|UNII-JGH0DF1U03|JGH0DF1U03|CB-228|3-(2-Amino-5-benzoxazolyl)-

规格或纯度：≥98%

英文名称：INK 128 (MLN0128)

生化机理：INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases [1]. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2. Furthermore, INK 128 also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg卖完停产，不再备货

产品介绍：INK 128是高活性mTOR抑制剂，IC50为1 nM，比对其它I型PI3K亚型的抑制性高200倍。A potent and selective TORC1/2 inhibitorINK 128 (MLN0128) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).A potent and selective TORC1/2 inhibitor

ALogP：1.7

IUPAC Name：5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine

INCHI：InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)

InChi Key：GYLDXIAOMVERTK-UHFFFAOYSA-N

Canonical SMILES：CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N

Isomeric SMILES：CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N

PubChem CID：45375953

CAS Registry No.：1224844-38-5

RCSB PDB Ligand：FE5

溶解性：DMSO

产品包装