产品名称

英文名称：Capmatinib (INCB28060)

同义词

capmatinib、1029712-80-8、INCB28060、INC280、INC-280、NVP-INC280-NX、NVP-INC280、INCB-28060、2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide、INCB-28060 FREE BASE、UNII-TY34L4F9OZ、TY34L4F9OZ、Capmatinib (INCB28060)、Capmatinib、INCB-28060、INC-280、苯扎米特、卡马替尼

产品性质

CAS编号：1029712-80-8

分子式：C23H17FN6O

分子量：412.42

PubChem编号：25145656

别名：INCB-28060|INC-280|苯扎米特|卡马替尼

英文别名：capmatinib|1029712-80-8|INCB28060|INC280|INC-280|NVP-INC280-NX|NVP-INC280|INCB-28060|2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide|INCB-28060 FREE BASE|UNII-TY34L4F9OZ|TY34L4F9OZ|Capmatinib (INCB28060)|Capmatinib

规格或纯度：≥98%

英文名称：Capmatinib (INCB28060)

生化机理：INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：INCB28060是高活性c-MET口服活性抑制剂，IC50为0.13 nM。A novel inhibitor of Met (IC50 = 0.13 nM)Capmatinib (INCB28060) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3.A novel inhibitor of Met (IC50 = 0.13 nM)

ALogP：2.9

IUPAC Name：2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

INCHI：InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

InChi Key：LIOLIMKSCNQPLV-UHFFFAOYSA-N

Canonical SMILES：CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

Isomeric SMILES：CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

PubChem CID：25145656

CAS Registry No.：1029712-80-8

ChEMBL Ligand：CHEMBL3188267

DrugCentral Ligand：5392

溶解性：25°C DMSO2mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn child

预防措施声明：P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P203,P301+P316,P318,P319

产品包装