产品名称

英文名称：ARN-509

同义词

apalutamide、ARN-509、956104-40-8、Erleada、JNJ-56021927、ARN 509、Apalutamide [INN]、ARN509、UNII-4T36H88UA7、4T36H88UA7、Apalutamide (ARN-509)、4-(7-(6-CYANO-5-(TRIFLUOROMETHYL)PYRIDIN-3-YL)-8-OXO-6-THIOXO-5,7-DIAZASPIRO[3.4]OCTAN-5-YL)-2-FLUORO-N-METHYLBENZAMIDE

产品性质

CAS编号：956104-40-8

分子式：C21H15F4N5O2S

分子量：477.43

PubChem编号：24872560

英文别名：apalutamide|ARN-509|956104-40-8|Erleada|JNJ-56021927|ARN 509|Apalutamide [INN]|ARN509|UNII-4T36H88UA7|4T36H88UA7|Apalutamide (ARN-509)|4-(7-(6-CYANO-5-(TRIFLUOROMETHYL)PYRIDIN-3-YL)-8-OXO-6-THIOXO-5,7-DIAZASPIRO[3.4]OCTAN-5-YL)-2-FLUORO-N-METHYLBENZAMIDE|

规格或纯度：≥98%

英文名称：ARN-509

生化机理：ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：ARN-509是竞争性雄激素受体抑制剂，IC50为16 nM，可作用于前列腺癌。ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment.

ALogP：3

IUPAC Name：4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide

INCHI：InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

InChi Key：HJBWBFZLDZWPHF-UHFFFAOYSA-N

Canonical SMILES：CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CC(=C(N=C4)C#N)C(F)(F)F)F

Isomeric SMILES：CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CC(=C(N=C4)C#N)C(F)(F)F)F

PubChem CID：24872560

ChEMBL Ligand：CHEMBL3183409

CAS Registry No.：956104-40-8

DrugCentral Ligand：5278

溶解性：DMSO 15 mg/mL Ethanol 5 mg/mL

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P391,P330,P203,P301+P317,P318,P319

产品包装