产品名称

英文名称：Letermovir

同义词

Letermovir、917389-32-3、AIC246、Prevymis、AIC-246、MK-8228、AIC 246、UNII-1H09Y5WO1F、1H09Y5WO1F、2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic acid、DTXSID40238683、2-[(4S)-8-fluoro-2-[4-(3

产品性质

CAS编号：917389-32-3

分子式：C29H28F4N4O4

分子量：572.55

PubChem编号：45138674

英文别名：Letermovir|917389-32-3|AIC246|Prevymis|AIC-246|MK-8228|AIC 246|UNII-1H09Y5WO1F|1H09Y5WO1F|2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic acid|DTXSID40238683|2-[(4S)-8-fluoro-2-[4-(3

规格或纯度：≥99%

英文名称：Letermovir

生化机理：DescriptionIC50 Value 5.1±1.2 nM (EC50, HCMV-AD169 strain, CPE reduction assay) [1]AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. AIC246 exhibits outstanding anti-HCMV activity in vitro and in vivo and currently is undergoing a clinical phase IIb trial.in vitro AIC246 blocks viral replication without inhibiting the synthesis of progeny HCMV DNA or viral proteins. Marker transfer analyses confirmed that these mutations were sufficient to mediate AIC246 resistance. The mapping of drμg resistance to open reading frame UL56 sμggests that viral DNA processing and/or packaging is targeted by AIC246. In line with this, we demonstrate that AIC246 affects the formation of proper unit-length genomes from viral DNA concatemers and interferes with virion maturation [2]. he anti-HCMV activity of AIC246 was evaluated in vitro and in vivo using various c

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。

ALogP：4.6

IUPAC Name：2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid

INCHI：InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1

InChi Key：FWYSMLBETOMXAG-QHCPKHFHSA-N

Canonical SMILES：COC1=C(C=C(C=C1)C(F)(F)F)N2C(C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O

Isomeric SMILES：COC1=C(C=C(C=C1)C(F)(F)F)N2[C@H](C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O

PubChem CID：45138674

溶解性：25°C DMSO

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P260,P203,P318,P319

产品包装