产品名称

英文名称：EMD638683

同义词

EMD638683、1181770-72-8、N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide、N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide、EMD-638683、SSNAPUUWBPZGOY-UHFFFAOYSA-N、GTPL9407、SCHEMBL6518734

产品性质

CAS编号：1181770-72-8

分子式：C18H18F2N2O4

分子量：364.34

PubChem编号：44182398

英文别名：EMD638683|1181770-72-8|N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide|N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide|EMD-638683|SSNAPUUWBPZGOY-UHFFFAOYSA-N|GTPL9407|SCHEMBL6518734

规格或纯度：98%

英文名称：EMD638683

生化机理：Description IC50 Value 3 μM EMD638683 is a SGK1 inhibitor.The serum- and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. EMD638683 could serve as a template for drμgs counteracting hypertension in individuals with type II diabetes and metabolic syndrome. in vitro EMD638683 was tested in vitro by determination of SGK1-dependent phosphorylation of NDRG1 (N-Myc downstream-regulated gene 1) in human cervical carcinoma HeLa-cells. EMD638683 was a SGK1 inhibitor with an IC50 of 3 μM[1]. in vivo Within 24 hours in vivo EMD638683 treatment significantly decreased blood pressure in fructose/saline-treated mice but not in control animals or in SGK1 knockout mice. EMD638683 failed to alter the blood pressure in SGK1 knockout mice. Following chronic (4 weeks) fructose/high salt treatment, additional EMD638683 treatment again decreased blood pressure. EMD638683 thus abrogates the salt sensitivity of blood pressure in hyperinsulinism without appreciably affecting blood pressure in the absence of hyperinsulinism. EMD638683 tended to increase fluid intake and urinary excretion of Na(+), significantly increased urinary flow rate and significantly decreased body weight[1]. Clinical trialN/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide

INCHI：InChI=1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)

InChi Key：SSNAPUUWBPZGOY-UHFFFAOYSA-N

Canonical SMILES：CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

Isomeric SMILES：CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

PubChem CID：44182398

CAS Registry No.：1181770-72-8

溶解性：25°C DMSO

产品包装