产品名称

英文名称：Tenofovir alafenamide

同义词

TENOFOVIR ALAFENAMIDE、379270-37-8、GS-7340、GS 7340、UNII-EL9943AG5J、EL9943AG5J、GS-734003、CHEBI90926、383365-04-6、Vemlidy、L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester、TAF、(S)-Isopropyl 2-((、(S)-2-(((S)-((((R)-1-(6-氨基-9H-嘌呤-9-基)丙-2-基)氧基)甲基)(苯氧基)磷酰基)氨基)丙酸异丙酯

产品性质

CAS编号：379270-37-8

分子式：C21H29N6O5P

分子量：476.47

PubChem编号：9574768

别名：(S)-2-(((S)-((((R)-1-(6-氨基-9H-嘌呤-9-基)丙-2-基)氧基)甲基)(苯氧基)磷酰基)氨基)丙酸异丙酯

英文别名：TENOFOVIR ALAFENAMIDE|379270-37-8|GS-7340|GS 7340|UNII-EL9943AG5J|EL9943AG5J|GS-734003|CHEBI90926|383365-04-6|Vemlidy|L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester|TAF|(S)-Isopropyl 2-((

规格或纯度：98%

英文名称：Tenofovir alafenamide

生化机理：Tenofovir alafenamide (TAF; GS-7340) is an isopropylalaninyl phenyl ester prodrug of the nucleotide analog reverse transcriptase inhibitor (nRTI) tenofovir (TFV) against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). GS-7340 more efficiently delivers TFV into lymphoid cells and tissues than tenofovir disoproxil fumarate (TDF), resulting in greater antiviral efficacy against HIV.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：产品介绍enofovir alafenamide (GS-7340) 是 Tenofovir 的前体，Tenofovir 是一种 HIV-1 核苷酸逆转录酶抑制剂。Product DescribtionTenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

ALogP：1.9

IUPAC Name：propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate

INCHI：InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1

InChi Key：LDEKQSIMHVQZJK-CAQYMETFSA-N

Canonical SMILES：CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3

Isomeric SMILES：C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3

PubChem CID：9574768

产品包装