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产品详情
产品名称 英文名称:AT406 (SM-406) 同义词 1071992-99-8、AT-406、Debio-1143、N65WC8PXDD、SM-406、UNII-N65WC8PXDD、Xevinapant、AT406、(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide、Debio 1143、QCR-136、AT 406、Debio114 产品性质 CAS编号:1071992-99-8 分子式:C32H43N5O4 分子量:561.71 PubChem编号:25022340 英文别名:1071992-99-8|AT-406|Debio-1143|N65WC8PXDD|SM-406|UNII-N65WC8PXDD|Xevinapant|AT406|(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide|Debio 1143|QCR-136|AT 406|Debio114 规格或纯度:≥98% 英文名称:AT406 (SM-406) 生化机理:AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. This may restore and promote the induction of apoptosis throμgh apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drμgs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. AT-406 is currently in Phase I clinical trial in patients with advanced solid tumors and lymphomas. 储存温度:-20°C储存 运输条件:超低温冰袋运输 产品介绍:Xevinapant (AT406, ARRY-334543, Debio1143, SM-406)是一种有效的,拟Smac的IAP(通过E3泛素连接酶起作用的凋亡蛋白抑制剂)拮抗剂,与XIAP-BIR3, cIAP1-BIR3和cIAP2-BIR3结合,Ki为66.4 nM, 1.9 nM和5.1 nM,比作用于Smac AVPI肽亲和力高50到100倍. IUPAC Name:(5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide INCHI:InChI=1S/C32H43N5O4/c1-21(2)19-28(38)36-18-17-25-15-16-27(37(25)32(41)26(20-36)34-30(39)22(3)33-4)31(40)35-29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-14,21-22,25-27,29,33H,15-20H2,1-4H3,(H,34,39)(H,35,40)/t22-,25+,26-,27-/m0/s1 InChi Key:LSXUTRRVVSPWDZ-MKKUMYSQSA-N Canonical SMILES:CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4 Isomeric SMILES:C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC PubChem CID:25022340 ChEMBL Ligand:CHEMBL2158051 CAS Registry No.:1071992-99-8 溶解性:DMSO 100 mg/mL Water <1 mg/mL Ethanol 100 mg/mL 产品包装
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