产品名称

英文名称：VUF 10166

同义词

155584-74-0、2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline、VUF 10166、Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-、CHEMBL261010、VUF10166、VUF10166;VUF-10166、2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline、SCHEMBL404203、DTXSID60640663、HMS3651F21、HMS3884N、2-氯-3-(4-甲基-1-哌嗪基)喹喔啉

产品性质

CAS编号：155584-74-0

分子式：C13H15ClN4

分子量：262.74

PubChem编号：24278976

别名：2-氯-3-(4-甲基-1-哌嗪基)喹喔啉

英文别名：155584-74-0|2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline|VUF 10166|Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-|CHEMBL261010|VUF10166|VUF10166;VUF-10166|2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline|SCHEMBL404203|DTXSID60640663|HMS3651F21|HMS3884N

规格或纯度：≥99%

英文名称：VUF 10166

生化机理：高亲和力5-HT3受体拮抗剂（人5HT3A和5-HT3AB受体的IC50值分别为0.04和22 nM）。在较高浓度下（EC50 =5.2μM），在5-HT3A受体处表现出部分激动剂活性。也是组胺H4受体拮抗剂（HEK细胞中pKi = 6.64）。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.

IUPAC Name：2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline

INCHI：InChI=1S/C13H15ClN4/c1-17-6-8-18(9-7-17)13-12(14)15-10-4-2-3-5-11(10)16-13/h2-5H,6-9H2,1H3

InChi Key：FFXVTQDGTKEXHF-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl

Isomeric SMILES：CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl

PubChem CID：24278976

溶解性：溶于DMSO, 最高浓度 (mg/mL) 26.27, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 26.27, 最高浓度(mM) 100

产品包装