产品名称

英文名称：PF-543

同义词

PF-543、1415562-82-1、PF 543、Sphingosine Kinase 1 Inhibitor II、PF543、CHEMBL3134157、[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol、{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PY

产品性质

CAS编号：1415562-82-1

分子式：C27H31NO4S

分子量：465.6

PubChem编号：66577038

英文别名：PF-543|1415562-82-1|PF 543|Sphingosine Kinase 1 Inhibitor II|PF543|CHEMBL3134157|[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol|{(2R)-1-[4-({3-METHYL-5-[(PHENYLSULFONYL)METHYL]PHENOXY}METHYL)BENZYL]PY

规格或纯度：98%

英文名称：PF-543

生化机理：PF-543 is a novel cell-permeant inhibitor of SphK1. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍PF-543 (Sphingosine Kinase 1 Inhibitor II) 是一种有效，选择性，可逆和鞘氨醇竞争性 SPHK1 抑制剂，IC50 为 2 nM，Ki 为 3.6 nM。PF-543 对 SPHK1 的选择性是 SPHK2 的 100 倍以上。PF-543 还是有效的全血中 1-磷酸鞘氨醇 (S1P) 形成的有效抑制剂，IC50 为 26.7 nM。PF-543 诱导细胞凋亡，坏死和自噬。product descriptionPF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.

IUPAC Name：[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol

INCHI：InChI=1S/C27H31NO4S/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3/t25-/m1/s1

InChi Key：NPUXORBZRBIOMQ-RUZDIDTESA-N

Canonical SMILES：CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4

Isomeric SMILES：CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[C@@H]3CO)CS(=O)(=O)C4=CC=CC=C4

PubChem CID：66577038

CAS Registry No.：1415562-82-1

ChEMBL Ligand：CHEMBL3134157

RCSB PDB Ligand：GYR

溶解性：DMSO mg/mL Water mg/mL Ethanol mg/mL

产品包装