产品名称

英文名称：IKK-16 (IKK Inhibitor VII)

同义词

873225-46-8、IKK Inhibitor VII、IKK 16、IKK-16、IKK16、IKK-16 (IKK Inhibitor VII)、IKK-16 (free base)、IKK-16(free base)、873225-46-8 (free base)、(4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone、CHEMBL200027、(

产品性质

CAS编号：873225-46-8

分子式：C28H29N5OS

分子量：483.63

PubChem编号：9549298

英文别名：873225-46-8|IKK Inhibitor VII|IKK 16|IKK-16|IKK16|IKK-16 (IKK Inhibitor VII)|IKK-16 (free base)|IKK-16(free base)|873225-46-8 (free base)|(4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone|CHEMBL200027|(

规格或纯度：≥99%

英文名称：IKK-16 (IKK Inhibitor VII)

生化机理：Description IC50 value 40nM( forIKK-2);70nM(for Ikk complex);200nM(for Ikk-1) IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. IKKs play an important role in the NF-KB signal pathway. In vitro K IKK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Althoμgh IKK-16 shows activity in the IFNγ-induced expression of β2 microglobulin or HLA-DR, its potency in these assays is 4- to 10-fold weaker. 1]. In vivo N/A Clinical trial N/A

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone

INCHI：InChI=1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31)

InChi Key：BWZJBXAPRCVCKQ-UHFFFAOYSA-N

Canonical SMILES：C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5

Isomeric SMILES：C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5

PubChem CID：9549298

溶解性：DMSO 97 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装