产品名称

英文名称：SAR131675

同义词

(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide、(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

产品性质

CAS编号：1433953-83-3

分子式：C18H22N4O4

分子量：358.39

PubChem编号：71295845

别名：(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

英文别名：(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

规格或纯度：98%

英文名称：SAR131675

生化机理：VEGFR-3 is a tyrosine kinase receptor recognized by VEGF-C and VEGF-D and plays a major role in lymphangiogenesis. A number of clinical and experimental studies have demonstrated that tumor lymphangiogenesis induced by VEGFR-3 promotes metastasis to regional lymph nodes. SAR131675 is a potent and selective VEGFR-3 inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. SAR131675 inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：SAR131675是一种VEGFR3抑制剂，无细胞试验中IC50/Ki为23 nM/12 nM，作用于VEGFR3比作用于VEGFR1/2选择性高50和10倍，对Akt1， CDKs， PLK1， EGFR， IGF-1R， c-Met， Flt2等几乎没有作用活性。

PubChem SID：488202179

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488202179

IUPAC Name：2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-ynyl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

INCHI：InChI=1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)/t18-/m1/s1

InChi Key：PFMPOBVAYMTUOX-GOSISDBHSA-N

Canonical SMILES：CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N

Isomeric SMILES：CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#C[C@](C)(COC)O)C(=O)NC)N

PubChem CID：71295845

溶解性：DMSO 30 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装