产品名称

英文名称：CB-839

同义词

CB-839、Telaglenastat、1439399-58-2、2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide、Telaglenastat [USAN]、CB839、CB-839(Telaglenastat)、CB 839、U6CL98GLP4、N-[6-(4-{5-[2-(pyridin-2-yl)ace

产品性质

CAS编号：1439399-58-2

分子式：C26H24F3N7O3S

分子量：571.57

PubChem编号：71577426

英文别名：CB-839|Telaglenastat|1439399-58-2|2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide|Telaglenastat [USAN]|CB839|CB-839(Telaglenastat)|CB 839|U6CL98GLP4|N-[6-(4-{5-[2-(pyridin-2-yl)ace

规格或纯度：98%

英文名称：CB-839

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

备注：5mg卖完停产，不再备货

产品介绍：产品介绍CB-839 (Telaglenastat) 是一种有效的，选择性的 glutaminase 抑制剂，对重组人GAC的 IC50 为 24 nM。CB-839(Telaglenastat)可诱导自噬并具有抗肿瘤活性。Biochemical mechanismCell permeable yesPrimary TargetGLS1Reversible yesTarget IC50 23 nM & 28 nM, respectively, using murine kidney and brain homogenates

ALogP：3.6

PubChem SID：488202265

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488202265

IUPAC Name：N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide

INCHI：InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)

InChi Key：PRAAPINBUWJLGA-UHFFFAOYSA-N

Canonical SMILES：C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F

Isomeric SMILES：C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F

PubChem CID：71577426

BindingDB Ligand：109086

CAS Registry No.：1439399-58-2

RCSB PDB Ligand：63J

溶解性：Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly

敏感性：对光线敏感

熔点：186- 189° C

产品包装