产品名称

英文名称：Meclizine 2HCl

同义词

Meclizine dihydrochloride、1104-22-9、Meclizine hydrochloride、Meclozine dihydrochloride、Bonamine、1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride、Ancolan dihydrochloride、Meclizine 2HCl、Diadril、Vertizine、Taizer、V-Cline、Meclizin、盐酸美克洛嗪

产品性质

CAS编号：1104-22-9

分子式：C25H27Cl2N2·2HCl

分子量：463.87

MDL号：MFCD00058199

PubChem编号：64713

别名：盐酸美克洛嗪

英文别名：Meclizine dihydrochloride|1104-22-9|Meclizine hydrochloride|Meclozine dihydrochloride|Bonamine|1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride|Ancolan dihydrochloride|Meclizine 2HCl|Diadril|Vertizine|Taizer|V-Cline|Meclizin

规格或纯度：≥98%

英文名称：Meclizine 2HCl

生化机理：人类孕烷X受体（hPXR）激动剂；比大鼠PXR更强的hPXR激活剂。增加人肝细胞原代培养物中的hPXR靶基因表达。还用作组胺H1受体拮抗剂。在polyQ毒性模型中赋予神经保护作用。

应用：A histamine H1 receptor antagonist and pregnane X receptor (PXR) agonist

储存温度：2-8°C储存

运输条件：冰袋运输

备注：25g卖完停产，不再备货

产品介绍：Meclizine 2HCl 是histamine H1 receptor拮抗剂,用于治疗恶心，晕动病，也是mCAR（组成型雄烷受体激动剂配体）激动剂配体，也是hCAR的反向激动剂。A histamine H1 receptor antagonist and pregnane X receptor (PXR) agonistMeclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.A histamine H1 receptor antagonist and pregnane X receptor (PXR) agonist

IUPAC Name：1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride

INCHI：InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H

InChi Key：VCTHNOIYJIXQLV-UHFFFAOYSA-N

Canonical SMILES：CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl

Isomeric SMILES：CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl

WGK Germany：3

RTECS：TL2005000

PubChem CID：64713

溶解性：溶于DMSO, 最高浓度 (mg/mL) 23.19, 最高浓度(mM) 50

敏感性：对热敏感

熔点：210-213°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P270,P330,P203,P301+P317,P318

产品包装