产品名称

英文名称：Loteprednol etabonate

同义词

Loteprednol etabonate、82034-46-6、Lotemax、Alrex、HGP-1、Inveltys、CDDD-5604、P-5604、CHEBI31784、CDDD 5604、UNII-YEH1EZ96K6、HGP 1、YEH1EZ96K6、EYSUVIS、DTXSID2046468、KPI-121、chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-o、氯替泼诺、HGP 1、(11β,17α)-17-[(乙氧羰基)氧]-11-羟基-3-氧代雄甾-1,4-二烯-17-羧酸氯甲酯

产品性质

CAS编号：82034-46-6

分子式：C24H31ClO7

分子量：466.95

MDL号：MFCD00870765

PubChem编号：444025

别名：氯替泼诺|HGP 1|(11β,17α)-17-[(乙氧羰基)氧]-11-羟基-3-氧代雄甾-1,4-二烯-17-羧酸氯甲酯

英文别名：Loteprednol etabonate|82034-46-6|Lotemax|Alrex|HGP-1|Inveltys|CDDD-5604|P-5604|CHEBI31784|CDDD 5604|UNII-YEH1EZ96K6|HGP 1|YEH1EZ96K6|EYSUVIS|DTXSID2046468|KPI-121|chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-o

规格或纯度：≥98%(HPLC)

英文名称：Loteprednol etabonate

生化机理：Loteprednol Etabonate is a "soft" steroid, typically used in topical applications for inflammatory conditions of the eye. Loteprednol Etabonate is an agonist of both glucocorticoid and mineralcorticoid receptors.

应用：An ophthalmic corticosteroid.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Loteprednol etabonate是一种用于眼科的抗炎皮质类固醇。An ophthalmic corticosteroid.Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology.An ophthalmic corticosteroid.

ALogP：3.9

IUPAC Name：chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate

INCHI：InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1

InChi Key：DMKSVUSAATWOCU-HROMYWEYSA-N

Canonical SMILES：CCOC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C(=O)OCCl

Isomeric SMILES：CCOC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C(=O)OCCl

WGK Germany：3

PubChem CID：444025

DrugBank Ligand：DB00873

CAS Registry No.：82034-46-6

ChEMBL Ligand：CHEMBL1200865

Wikipedia：Loteprednol

PEP：loteprednol

DrugCentral Ligand：1611

溶解性：DMSO 93 mg/mL Water Ethanol 4 mg/mL

敏感性：对热敏感

比旋光度：40° (C=1,Dioxane)

熔点：226-233°C

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P362+P364,P330,P263,P203,P301+P317,P318,P317,P319

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