产品名称

英文名称：Nateglinide

同义词

AKOS000268454、DJN 608、HY-B0422、Nateglinide (Starlix)、Nateglinide impurity C [EP]、NATEGLINIDE [MI]、NC00148、SCHEMBL303827、2,6-Diamino-4(3H)-pyrimidinone、n-(trans-4-Isopropylcylolohexylcarboxyl)-d-phenylpropylicacid、NSC-4918、NSC-758695、UNII-XTM4DQP5S5、D-Phen、那格列奈

产品性质

CAS编号：105816-04-4

分子式：C19H27NO3

分子量：317.43

MDL号：MFCD00875706

PubChem编号：5311309

别名：那格列奈

英文别名：AKOS000268454|DJN 608|HY-B0422|Nateglinide (Starlix)|Nateglinide impurity C [EP]|NATEGLINIDE [MI]|NC00148|SCHEMBL303827|2,6-Diamino-4(3H)-pyrimidinone|n-(trans-4-Isopropylcylolohexylcarboxyl)-d-phenylpropylicacid|NSC-4918|NSC-758695|UNII-XTM4DQP5S5|D-Phen

规格或纯度：≥99%

英文名称：Nateglinide

生化机理：Kir6（KATP）阻滞剂。与心血管Kir6通道相比，胰腺组织对胰β细胞型Kir6通道的选择性更高；对SUR1 / Kir6.2通道显示高亲和力。降糖药；通过增加胞浆中Ca2 +的浓度刺激胰腺β细胞分泌胰岛素。也是孤儿受体MRGPRX4的激动剂。

应用：An amino-acid derivative that stimulates insulin secretion

储存温度：室温

运输条件：常规运输

备注：250mg卖完停产，不再备货

产品介绍：Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of theβ cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.An amino-acid derivative that stimulates insulin secretionNateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of theβ cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.An amino-acid derivative that stimulates insulin secretion

PubChem SID：488195310

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195310

IUPAC Name：(2R)-3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoic acid

INCHI：InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15?,16?,17-/m1/s1

InChi Key：OELFLUMRDSZNSF-OFLPRAFFSA-N

Canonical SMILES：CC(C)C1CCC(CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)O

Isomeric SMILES：CC(C)C1CCC(CC1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)O

WGK Germany：3

RTECS：SQ7318950

PubChem CID：5311309

Reaxy-Rn：6486870

DrugBank Ligand：DB00731

CAS Registry No.：105816-04-4

ChEMBL Ligand：CHEMBL783

Wikipedia：Nateglinide

PEP：nateglinide

DrugCentral Ligand：1886

溶解性：溶于DMSO, 最高浓度 (mg/mL) 31.74, 最高浓度(mM) 100

比旋光度：-38° (C=1,0.1mol/L NaHO sol.)

Merck Index：6428

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装