产品名称

英文名称：Pinacidil monohydrate

同义词

PINACIDIL MONOHYDRATE、85371-64-8、Pindac、Pinacidil hydrate、Pinacidil (monohydrate)、7B0ZZH8P2W、DTXSID4045682、CHEBI34923、UNII-7B0ZZH8P2W、Pinacidil (USAN)、Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (11)、PINACIDIL [USAN]、1-cyano-2、(±)-N-氰基-N'-4-吡啶-N″-(1,2,2-三甲基丙基)胍 一水合物

产品性质

CAS编号：85371-64-8

分子式：C13H19N5 · H2O

分子量：263.34

EC号：262-294-9

MDL号：MFCD00242745

PubChem编号：55329

别名：(±)-N-氰基-N'-4-吡啶-N″-(1,2,2-三甲基丙基)胍 一水合物

英文别名：PINACIDIL MONOHYDRATE|85371-64-8|Pindac|Pinacidil hydrate|Pinacidil (monohydrate)|7B0ZZH8P2W|DTXSID4045682|CHEBI34923|UNII-7B0ZZH8P2W|Pinacidil (USAN)|Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (11)|PINACIDIL [USAN]|1-cyano-2

规格或纯度：98%

英文名称：Pinacidil monohydrate

生化机理：K+ 通道激活剂；降压药。 吡那地尔是一种KATP通道激动剂。它可通过防止线粒体膜电位的丢失来保护心肌细胞。它可以防止缺氧/复氧损伤中半胱天冬酶3的激活。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：应用使用吡那地尔通过注入左前降支用于复极化研究在心室肌细胞中诱导ATP敏感性K+ (KATP)电流，用于电生理检查作为KATP开启剂来治疗心肌细胞Pinacidil is a K+ channel opener. Pinacidil is demonstrated to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. This action is suppressed by the ATP-dependent K+ (KATP) channel blockers Glibenclamide and Tetrapentylammonium salts, suggesting that relaxations induced by Pinacidil are mediated by opening of KATP channels.A K+ channel activator; antihypertensiveApplicationUse pinacidilRepolarization study by injection of left anterior descending branchInduction of ATP sensitive K + (KATP) currents in ventricular myocytes for electrophysiological examinationAs a KATP opener to treat cardiomyocytes

IUPAC Name：1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine;hydrate

INCHI：InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2

InChi Key：AFJCNBBHEVLGCZ-UHFFFAOYSA-N

Canonical SMILES：CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1.O

Isomeric SMILES：CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1.O

WGK Germany：3

PubChem CID：55329

溶解性：Soluble in 100% ethanol (14 mg/ml), DMSO (15 mg/ml), dilute aqueous acid, and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (40 mg/ml). Insoluble in water

敏感性：对湿度敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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