产品名称

英文名称：Everolimus

同义词

EVEROLIMUS (USP-RS)、EVEROLIMUS [MI]、Votubia、5-methyl-5-phenyl-barbituric acid、DTXCID8020599、EVEROLIMUS [VANDF]、Everolimus tablets、RAD, SDZ、AKOS015907063、L04AA18、SDZ RAD、UNII-9HW64Q8G6G、Tox21_112510、(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS、依维莫司

产品性质

CAS编号：159351-69-6

分子式：C53H83NO14

分子量：958.25

PubChem编号：6442177

别名：依维莫司

英文别名：EVEROLIMUS (USP-RS)|EVEROLIMUS [MI]|Votubia|5-methyl-5-phenyl-barbituric acid|DTXCID8020599|EVEROLIMUS [VANDF]|Everolimus tablets|RAD, SDZ|AKOS015907063|L04AA18|SDZ RAD|UNII-9HW64Q8G6G|Tox21_112510|(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS

规格或纯度：≥98%

英文名称：Everolimus

生化机理：Everolimus is a macrolide derived from rapamycin with immunosuppressant properties shown to inhibit cell proliferation induced by growth factors. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Studies indicate that everolimus is a mTOR (FRAP) inhibitor that displays high affinity toward the intracellular receptor FKBP12. Additionally, the Everolimus-FKBP12 complex decreases the activity of the S6K1 and 4EBP by binding to FRAP.Potent mTOR inhibitor (IC 50 = 1.6 - 2.4 nM). Immunosupressant and anticancer activity in vivo . Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Everolimus (RAD001)是一种mTOR抑制剂，作用于FKBP12，IC50为1.6-2.4 nM。An immunosuppresive inhibitor of FRAP (mTOR).Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.An immunosuppresive inhibitor of FRAP (mTOR).

ALogP：5.9

PubChem SID：488195795

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195795

IUPAC Name：(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

INCHI：InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChi Key：HKVAMNSJSFKALM-GKUWKFKPSA-N

Canonical SMILES：CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC

Isomeric SMILES：C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC

PubChem CID：6442177

DrugBank Ligand：DB01590

CAS Registry No.：159351-69-6

Wikipedia：Everolimus

ChEMBL Ligand：CHEMBL1908360

PEP：everolimus

DrugCentral Ligand：1118

溶解性：Soluble in chloroform, methanol, DMSO (100 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (100 mg/ml).

象形图：

信号词：Danger

危险声明：H412 Harmful to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P273,P501,P264,P260,P270,P319

产品包装