产品名称

英文名称：Salirasib

同义词

Salirasib、162520-00-5、Farnesylthiosalicylic acid、S-Farnesylthiosalicylic acid、Farnesyl Thiosalicylic Acid、MZH0OM550M、2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzoic acid、CHEMBL23293、2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfan

产品性质

CAS编号：162520-00-5

分子式：C22H30O2S

分子量：358.54

MDL号：MFCD00467723

PubChem编号：5469318

英文别名：Salirasib|162520-00-5|Farnesylthiosalicylic acid|S-Farnesylthiosalicylic acid|Farnesyl Thiosalicylic Acid|MZH0OM550M|2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzoic acid|CHEMBL23293|2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfan

规格或纯度：≥98%

英文名称：Salirasib

生化机理：Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Salirasib binds to a cell membrane anchor protein thereby selectively blocking a cascade of biochemical signals known as the Ras signaling pathway. The Ras pathway plays an important role in tumor growth and is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Up to 90% of human pancreatic cancers are driven by aberrant oncogenic Ras signaling.Competitive PPMTase inhibitor (K i = 2.6 μM). Ras inhibitor. Facilitates ras degradation, displacement from the plasma membrane and downstream signaling. Shows antiproliferative effects (IC 50 = 7.5 µM, Rat1 fibroblasts).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Salirasib是一种有效的竞争性prenylated protein methyltransferase (PPMTase)抑制剂， Ki为2.6 μM，其抑制Ras甲基化。Phase 2。Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.

ALogP：7.2

IUPAC Name：2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzoic acid

INCHI：InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+

InChi Key：WUILNKCFCLNXOK-CFBAGHHKSA-N

Canonical SMILES：CC(=CCCC(=CCCC(=CCSC1=CC=CC=C1C(=O)O)C)C)C

Isomeric SMILES：CC(=CCC/C(=C/CC/C(=C/CSC1=CC=CC=C1C(=O)O)/C)/C)C

PubChem CID：5469318

CAS Registry No.：162520-00-5

ChEMBL Ligand：CHEMBL23293

溶解性：DMSO <20mg/mL; Ethanol <20mg/mL; DMF <20mg/mL

敏感性：对光敏感、对空气敏感、对热敏感

熔点：72 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritation

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P264,P362+P364,P264+P265,P337+P317,P332+P317

产品包装