产品名称

英文名称：Pifithrin-α (PFTα)

同义词

Pifithrin-alpha、63208-82-2、PFT-alpha、Pifithrin-alpha hydrobromide、Pifithrin hydrobromide、Pifithrin-、Pifithrin-a hydrobromide、2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide、2-(2-imino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-、皮斐松、2-(2-亚氨基-4,5,6,7-四氢苯并噻唑-3-基)-1-p-甲苯基乙酮氢溴酸盐、吡菲他林-α

产品性质

CAS编号：63208-82-2

分子式：C16H18N2OS·HBr

分子量：367.3

MDL号：MFCD00417851

PubChem编号：9929138

别名：皮斐松|2-(2-亚氨基-4,5,6,7-四氢苯并噻唑-3-基)-1-p-甲苯基乙酮氢溴酸盐|吡菲他林-α

英文别名：Pifithrin-alpha|63208-82-2|PFT-alpha|Pifithrin-alpha hydrobromide|Pifithrin hydrobromide|Pifithrin-|Pifithrin-a hydrobromide|2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide|2-(2-imino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-

规格或纯度：≥97%

英文名称：Pifithrin-α (PFTα)

生化机理：Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. It enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin , etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation, and does not induce visible tumors. Protects against neuronal death in models of stroke and neurodegenerative disorders. Pifithrin-α is also an aryl hydrocarbon receptor (AHR) agonist, which leads to the upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).p53 Inhibitor. Specifically blocks tumor supressor p53 transcriptional activity and can supress heat shock and glucocorticoid signalling pathways. Additionally offers protection to cells from p53 mediated apoptosis. Active in vivo

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pifithrin-α (PFTα)是一种p53抑制剂，抑制p53依赖性的p53应答基因转录。An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis.Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.An inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis.

PubChem SID：488196441

IUPAC Name：2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone;hydrobromide

INCHI：InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H

InChi Key：HAGVCKULCLQGRF-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br

Isomeric SMILES：CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br

WGK Germany：3

PubChem CID：9929138

溶解性：Soluble in DMSO (20 mg/ml), water, DMF (~1 mg/ml), 110 DMSOPBS (pH 7.2) (~ 0.1 mg/ml), 100% ethanol, and methanol. Sparingly soluble in aqueous buffers.

敏感性：对光和热敏感

熔点：192 °C

Merck Index：7421

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装