产品名称

英文名称：Nafamostat Mesylate

同义词

Nafamostat mesylate、82956-11-4、Futhan、nafamostat mesilate、FUT-175、Nafamostat (mesylate)、Nafamstat Mesilate、Ronastat、Nafamostat mesylate [USAN]、6-Carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate dimethanesulfonate、Nafamstat、Nafamostat mesylate (USAN)、6-[am、甲磺酸萘莫司他、FUT-175、6-甲脒基-2-萘基-4-胍基苯甲酸酯二(甲磺酸盐)、4-胍基苯甲酸6-甲脒基-2-萘基酯双(甲磺酸盐)

产品性质

CAS编号：82956-11-4

分子式：C19H17N5O2·2CH4O3S

分子量：539.58

MDL号：MFCD00941430

PubChem编号：5311180

别名：甲磺酸萘莫司他|FUT-175|6-甲脒基-2-萘基-4-胍基苯甲酸酯二(甲磺酸盐)|4-胍基苯甲酸6-甲脒基-2-萘基酯双(甲磺酸盐)

英文别名：Nafamostat mesylate|82956-11-4|Futhan|nafamostat mesilate|FUT-175|Nafamostat (mesylate)|Nafamstat Mesilate|Ronastat|Nafamostat mesylate [USAN]|6-Carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate dimethanesulfonate|Nafamstat|Nafamostat mesylate (USAN)|6-[am

规格或纯度：≥98%

英文名称：Nafamostat Mesylate

生化机理：Nafamostat mesylate is a highly effective tryptase (Ki=95.3 pM) inhibitor. The compound has the ability to promote synthesis of interferon-γ, tumor necrosis factor-α, IL-12, and IL-18. Additionally, Nafamostat mesylate can induce production of intercellular adhesion molecules-1, B7.1, B7.2, CD40 and CD40 ligand in human blood mononuclear cells. Nafamostat mesylate is an anticoagulant and has been shown to decrease levels of plasma myeloperoxidase, and has also been used in ERCP pancreatitis studies. Nafamostat mesylate is an inhibitor of Factor X, Factor XII, granzyme A and KLK.Broad spectrum, potent protease inhibitor (K i = 95.3 pM). Inhibits NF-κB activation and complement activation. Selective for human tryptase.

储存温度：2-8°C储存,避光

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nafamostat Mesylate是一种抗凝血剂。A highly effective tryptase inhibitor.Nafamostat甲磺酸盐是广谱的丝氨酸蛋白酶抑制剂，血管舒缓素抑制剂，能抑制血液凝固，还是潜在的补体抑制剂。Nafamostat甲磺酸盐通过降低颗粒酶活性和 CTL 细胞溶解抑制T细胞自身反应活性。Nafamostat mesylate 可抑制SARS-CoV-2 的激活。Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis.A highly effective tryptase inhibitor.

PubChem SID：488195307

IUPAC Name：(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate;methanesulfonic acid

INCHI：InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)

InChi Key：SRXKIZXIRHMPFW-UHFFFAOYSA-N

Canonical SMILES：CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

Isomeric SMILES：CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

RTECS：DG2736000

PubChem CID：5311180

溶解性：Soluble in DMSO (>10 mg/ml), water (25 mg/ml) Note Phosphate-containing buffers may cause precipitation, and ethanol (<1 mg/mL) at 25 °C.

敏感性：对湿度敏感，对光敏感

熔点：260°C

象形图：

信号词：Warning

危险声明：H361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

Merck Index：6350

个人防护装备：Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

产品包装