产品名称

英文名称：Vandetanib

同义词

ZD6474 、 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine 、 N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine、凡德他尼

产品性质

CAS编号：443913-73-3

分子式：C22H24BrFN4O2

分子量：475.36

PubChem编号：3081361

别名：凡德他尼

英文别名：ZD6474 | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

规格或纯度：≥99%

英文名称：Vandetanib

生化机理：Vandetanib is an orally active and potent inhibitor of vascular endothelial growth factor receptor receptor 2 (VEGFR2) kinase activity that is used to treat medullary thyroid cancer. Vandetanib also inhibits epidermal growth factor receptor (EGFR), and RET tyrosine kinases.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families. Specifically inhibits kinase activity of Flk-1. Vandetanib is an inhibitor of Flt-4.An antagonist of VEGFR (Flk and Flk) and EGFR families.Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families. Specifically inhibits kinase activity of Flk-1. Vandetanib is an inhibitor of Flt-4.An antagonist of VEGFR (Flk and Flk) and EGFR families.

IUPAC Name：N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

INCHI：InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)

InChi Key：UHTHHESEBZOYNR-UHFFFAOYSA-N

Canonical SMILES：CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

Isomeric SMILES：CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

PubChem CID：3081361

CAS Registry No.：443913-73-3

Wikipedia：Vandetanib

DiscoveRx TREEspot：Vandetanib|

DrugBank Ligand：DB05294

ChEMBL Ligand：CHEMBL24828

RCSB PDB Ligand：ZD6

Reactome Reaction：R-HSA-1220610

Reactome Drug：R-ALL-1216528

DrugCentral Ligand：4178

溶解性：Soluble in methanol, DMSO (4 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn childH360Df May damage the unborn child; Suspected of damaging fertility

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

产品包装