产品名称

英文名称：cholest-(25R)-5-ene-3β,27-diol

同义词

27-hydroxycholesterol、20380-11-4、(25R)-26-Hydroxycholesterol、(25R)-Cholest-5-ene-3beta,26-diol、Cholest-5-ene-3beta,27-diol、cholest-(25R)-5-en-3beta,26-diol、6T2NA6P5SQ、27-hydroxy-cholesterol(25R)、25(R)-27-hydroxy Cholesterol、CHEBI76591、(3S,8S,9S,10R,13R,1、27-羟基胆固醇、25(R)-27-羟基胆固醇、27-OHC、(25R)-26-羟基胆固醇、(25R)-胆甾-5-烯-3b、26-二醇、27-羟基胆固醇(25R)、胆甾-5-ene-3β,27-二醇、(25R)、11081825(R)-27-羟基胆固醇、27-OHC、(25R)-26-羟基胆固醇、(25R)-胆甾-5-烯-3b、26-二醇、27-羟基胆固醇(25R)、胆甾-5-ene-3β,27-二醇、(25R)、110818

产品性质

CAS编号：20380-11-4

分子式：C27H46O2

分子量：402.65

PubChem编号：123976

别名：27-羟基胆固醇|25(R)-27-羟基胆固醇|27-OHC|(25R)-26-羟基胆固醇|(25R)-胆甾-5-烯-3b|26-二醇|27-羟基胆固醇(25R)|胆甾-5-ene-3β,27-二醇|(25R)|11081825(R)-27-羟基胆固醇|27-OHC|(25R)-26-羟基胆固醇|(25R)-胆甾-5-烯-3b|26-二醇|27-羟基胆固醇(25R)|胆甾-5-ene-3β,27-二醇|(25R)|110818

英文别名：27-hydroxycholesterol|20380-11-4|(25R)-26-Hydroxycholesterol|(25R)-Cholest-5-ene-3beta,26-diol|Cholest-5-ene-3beta,27-diol|cholest-(25R)-5-en-3beta,26-diol|6T2NA6P5SQ|27-hydroxy-cholesterol(25R)|25(R)-27-hydroxy Cholesterol|CHEBI76591|(3S,8S,9S,10R,13R,1

规格或纯度：>99%

英文名称：cholest-(25R)-5-ene-3β,27-diol

生化机理：LXR激动剂。雌激素受体部分激动剂。\ xa0调节乳腺癌细胞系中的基因表达。

应用：An oxysterol with cholesterol oxidation metabolite properties.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：27-羟基胆固醇（27-HC）是由胆固醇在肝脏中的甾醇27-羟化酶作用下合成的。在0.15至0.73 μM的循环范围中，它是一种丰富的氧化甾醇。27-HC是胆汁合成的底物 应用观察其对肝脏脂质积累的抑制作用；作为乳腺癌细胞系中的肝X受体(LXR)配体；作为液相色谱-串联质谱(LC-MS-MS)法中的对照，量化空肠样品中的25-OHC 27-hydroxycholesterol (27-HC) is synthesized by cholesterol under the action of sterol 27-hydroxylase in the liver. It is an abundant oxidizing sterol in the cyclic range of 0.15 to 0.73 μM. 27-HC is a substrate for bile synthesis Product description27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol has also been reported to increase levels of Aβ peptide production, reduce mitochondrial membrane potential, and induce nuclear factor κB (NFκB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is an activator of LXR α and LXR β.An oxysterol with cholesterol oxidation metabolite properties.Application To observe its inhibitory effect on lipid accumulation in liver. As a liver X receptor (LXR) ligand in breast cancer cell lines; As a control in liquid chromatography-tandem mass spectrometry (LC-MS-MS), 25-OHC in jejunum samples was quantified

IUPAC Name：(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

INCHI：InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChi Key：FYHRJWMENCALJY-YSQMORBQSA-N

Canonical SMILES：CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO

Isomeric SMILES：C[C@H](CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)CO

PubChem CID：123976

CAS Registry No.：20380-11-4

ChEMBL Ligand：CHEMBL353882

BindingDB Ligand：20183

ChEBI：CHEBI76591

Wikipedia：27-Hydroxycholesterol

GPCRdb Ligand：27-hydroxycholesterol

溶解性：≤20mg/ml in ethanol;0.1mg/ml in DMSO;2mg/ml in dimethyl formamide

产品包装