产品名称

英文名称：Miglustat

同义词

NB-DNJ 、 1,5-(Butylimino)-1,5-dideoxy-D-glucitol(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol 、 N-(n-Butyl)-1-deoxynojirimycin min. 99% 、 N-Butyldeoxynojirimycin 、 Zavesca 、 OGT-918 、 1,5-(BUTYLIMINO)-1,5-DIDEOXY-D-GLUCITOL 、 3,4,5-Piperid

产品性质

CAS编号：72599-27-0

分子式：C10H21NO4

分子量：219.28

MDL号：MFCD00272581

PubChem编号：51634

英文别名：NB-DNJ | 1,5-(Butylimino)-1,5-dideoxy-D-glucitol(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol | N-(n-Butyl)-1-deoxynojirimycin min. 99% | N-Butyldeoxynojirimycin | Zavesca | OGT-918 | 1,5-(BUTYLIMINO)-1,5-DIDEOXY-D-GLUCITOL | 3,4,5-Piperid

规格或纯度：98%

英文名称：Miglustat

生化机理：N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Miglustat(OGT918)是葡萄糖神经酰胺合成酶抑制剂，可作用于I型戈谢病.Product ApplicationN-Butyldeoxynojirimycin has been usedin the inhibition of glycolipid synthesis in neuroblastoma cellsin the inhibition the ceramide-specific glycosyltransferase in hepatocytesin the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

IUPAC Name：(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol

INCHI：InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1

InChi Key：UQRORFVVSGFNRO-UTINFBMNSA-N

Canonical SMILES：CCCCN1CC(C(C(C1CO)O)O)O

Isomeric SMILES：CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O

PubChem CID：51634

DrugBank Ligand：DB00419

CAS Registry No.：72599-27-0

Wikipedia：Miglustat

ChEMBL Ligand：CHEMBL1029

RCSB PDB Ligand：NBV

Reactome Reaction：R-HSA-9686790

Reactome Drug：R-ALL-9686843

DrugCentral Ligand：1807

溶解性：Soluble in water at 10mg/ml

熔点：126-127℃

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn childH361fd Suspected of damaging fertility; Suspected of damaging the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P263,P203,P264+P265,P301+P317,P318,P317,P337+P317,P332+P317,P319

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