阿比特龙

产品分类

应用/药物靶标/酶/细胞色素P450

产品名称

中文名称：阿比特龙

英文名称：Abiraterone

同义词

BDBM25458、CB-7598、GZOSMCIZMLWJML-VJLLXTKPSA-N、L02BX03、17-(3-Pyridyl)androsta-5,16-dien-3.beta.-ol、Abiraterone- Bio-X、NSC749226、2-Phenylindandione、ABIRATERONE (USP IMPURITY)、AKOS005146525、CCRIS 6832、DTXCID501021626、(3beta)-17-(pyridin-3-yl)androsta-5,16-di、阿比特龙

产品性质

CAS编号：154229-19-3

分子式：C24H31NO

分子量：349.52

PubChem编号：132971

规格或纯度：≥99%

英文名称：Abiraterone

生化机理：Abiraterone (CB-7598, CB7598, CB 7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Abiraterone是一种有效的类固醇细胞色素P450 17alpha-羟化酶-17， 20-裂解酶(CYP17)抑制剂，IC50为2 nM。Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM.

ALogP：4.6

IUPAC Name：(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol

INCHI：InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1

InChi Key：GZOSMCIZMLWJML-VJLLXTKPSA-N

Canonical SMILES：CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O

PubChem CID：132971

ChEBI：CHEBI68642

CAS Registry No.：154229-19-3

DrugBank Ligand：DB05812

ChEMBL Ligand：CHEMBL254328

RCSB PDB Ligand：AER

PEP：abiraterone

溶解性：DMSO 0.1 mg/mL Water 0.02 mg/mL Ethanol 0.2 mg/mL

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH360F May damage fertilityH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P260,P391,P203,P318,P319

产品包装