产品名称

英文名称：Bazedoxifene

同义词

Bazedoxifene、198481-32-2、Bazedoxifene [INN]、TSE-424、1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-、Bazedoxifene free base、Q16TT9C5BK、1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H

产品性质

CAS编号：198481-32-2

分子式：C30H34N2O3

分子量：470.6

PubChem编号：154257

英文别名：Bazedoxifene|198481-32-2|Bazedoxifene [INN]|TSE-424|1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-|Bazedoxifene free base|Q16TT9C5BK|1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H

规格或纯度：98%

英文名称：Bazedoxifene

生化机理：Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment. Preclinical and clinical studies with bazedoxifene demonstrate more tissue selectivity than other SERMs. In particular, bazedoxifene has minimal if any agonist activity in the uterus and is able to antagonize effects of estrogen on the uterus. Animal studies and early clinical studies sμggest effects in the bone similar to other SERMs with prevention of postmenopausal bone loss.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Bazedoxifene是一种第三代选择性雌激素受体调节剂。 Bazedoxifene (TSE-424) 是一种能透过血脑屏障的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的 IC50 值分别为 26 nM 和 99 nM，可用于骨质疏松症的研究。Bazedoxifene 也是一种 IL-6/GP130 蛋白相互作用抑制剂，可用于胰腺癌的研究。

IUPAC Name：1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

INCHI：InChI=1S/C30H34N2O3/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31/h6-15,20,33-34H,2-5,16-19,21H2,1H3

InChi Key：UCJGJABZCDBEDK-UHFFFAOYSA-N

Canonical SMILES：CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O

Isomeric SMILES：CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O

PubChem CID：154257

ChEMBL Ligand：CHEMBL46740

CAS Registry No.：198481-32-2

Wikipedia：Bazedoxifene

RCSB PDB Ligand：29S

DrugCentral Ligand：4334

溶解性：氯仿（轻微）、二甲基亚砜（轻微）、甲醇（轻微）

象形图：

信号词：Danger

危险声明：H360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P203,P318

产品包装