产品名称

英文名称：Canertinib (CI-1033)

同义词

Canertinib、267243-28-7、CI-1033、PD-183805、Canertinib free base、N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide、N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide、N-[4-(3-c、PD-183805、卡奈替尼、卡耐替尼

产品性质

CAS编号：267243-28-7

分子式：C24H25ClFN5O3

分子量：485.94

PubChem编号：156414

别名：PD-183805|卡奈替尼|卡耐替尼

英文别名：Canertinib|267243-28-7|CI-1033|PD-183805|Canertinib free base|N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide|N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide|N-[4-(3-c

规格或纯度：≥98%

英文名称：Canertinib (CI-1033)

生化机理：Canertinib is a potent and selective inhibitor of tyrosine residue phosphorylation of EGFR, blocking signal transgression and ceasing angiogenisis. Canertinib displays an IC50 = 1.5nM. Additionally, Canertinib’s action in inhibiting EGFR increases apoptosis in cancerous cell lines in a titratable fashion.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Canertinib (CI-1033)是一种pan-ErbB抑制剂，同时抑制EGFR和ErbB2，IC50分别为1.5 nM和9.0 nM，但对PDGFR， FGFR， InsR， PKC，和CDK1/2/4等均无抑制活性。An irreversible pan-erbB tyrosine kinase inhibitor.Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4.An irreversible pan-erbB tyrosine kinase inhibitor.

IUPAC Name：N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide

INCHI：InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)

InChi Key：OMZCMEYTWSXEPZ-UHFFFAOYSA-N

Canonical SMILES：C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

Isomeric SMILES：C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

PubChem CID：156414

CAS Registry No.：267243-28-7

Wikipedia：Canertinib

DiscoveRx TREEspot：CI-1033|

ChEMBL Ligand：CHEMBL31965

Reactome Reaction：R-HSA-1220611, R-HSA-1225978, R-HSA-9652264, R-HSA-9665121

Reactome Drug：R-ALL-1227677

溶解性：Soluble in DMSO (2 mg/ml), methanol, ethanol (9 mg/ml), and water (<1 mg/ml).

产品包装