产品名称

英文名称：Motesanib

同义词

N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide、NSC800801、NSC-800801、HMS3244B09、HY-10228、N-(3,3-Dimethyl-2,3-dihydro-1H-indol-6-yl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide、SCHEMBL2416976、D06678、GTPL5660、莫特塞尼

产品性质

CAS编号：453562-69-1

分子式：C22H23N5O

分子量：373.46

PubChem编号：11667893

别名：莫特塞尼

英文别名：N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide|NSC800801|NSC-800801|HMS3244B09|HY-10228|N-(3,3-Dimethyl-2,3-dihydro-1H-indol-6-yl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide|SCHEMBL2416976|D06678|GTPL5660

规格或纯度：≥98%

英文名称：Motesanib

生化机理：Motesanib is an inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Motesanib (AMG-706)是ATP竞争性VEGFR1，2，3抑制剂，IC50分别为 2 nM，3 nM和6 nM，对c-Kit的IC50为8 nM。An inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret.An inhibitor of Flk-1, Flt-4, PDGFR-β and c-Kit.

ALogP：3.9

IUPAC Name：N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide

INCHI：InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)

InChi Key：RAHBGWKEPAQNFF-UHFFFAOYSA-N

Canonical SMILES：CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

Isomeric SMILES：CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

PubChem CID：11667893

CAS Registry No.：453562-69-1

Wikipedia：Motesanib

DiscoveRx TREEspot：AMG-706|

ChEMBL Ligand：CHEMBL572881

RCSB PDB Ligand：706

溶解性：DMSO

产品包装