产品名称

英文名称：Bimatoprost

同义词

AGN 192024 、 (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(S,E)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide 、 17-Phenyltrinor-PGF2α Ethylamide、(Z)-7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(S,E)-3-羟基-5-苯基戊-1-烯-1-基]环戊基]-N-乙基庚-5-烯酰胺 、 17-苯基trinor-PGF2α乙酰胺 、 17-苯基-三-去甲前列腺素 F 2α-乙酰胺

产品性质

CAS编号：155206-00-1

分子式：C25H37NO4

分子量：415.57

MDL号：MFCD03411999

PubChem编号：5311027

别名：(Z)-7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(S,E)-3-羟基-5-苯基戊-1-烯-1-基]环戊基]-N-乙基庚-5-烯酰胺 | 17-苯基trinor-PGF2α乙酰胺 | 17-苯基-三-去甲前列腺素 F 2α-乙酰胺

英文别名：AGN 192024 | (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(S,E)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide | 17-Phenyltrinor-PGF2α Ethylamide

规格或纯度：≥99%

英文名称：Bimatoprost

生化机理：Bimatoprost is converted by an amidase enzymatic activity in bovine and human cornea models to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：Bimatoprost 是一种前列腺素类似物，可用于高眼压和青光眼的研究，也具有抗脂肪形成作用 应用强效 FP 前列腺素受体激动剂在青光眼动物模型中的应用 Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects

ALogP：2.8

IUPAC Name：(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide

INCHI：InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1

InChi Key：AQOKCDNYWBIDND-FTOWTWDKSA-N

Canonical SMILES：CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O

Isomeric SMILES：CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O

WGK Germany：3

PubChem CID：5311027

DrugBank Ligand：DB00905

CAS Registry No.：155206-00-1

Wikipedia：Bimatoprost

ChEBI：CHEBI51230

ChEMBL Ligand：CHEMBL1200963

RCSB PDB Ligand：15M

PEP：bimatoprost

DrugCentral Ligand：371

GPCRdb Ligand：bimatoprost

溶解性：Soluble in ethanol (~50 mg/ml), methanol, DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~300 ug/ml).

敏感性：对空气敏感，对热敏感，对光敏感

比旋光度：35° (C=1,MeOH)

熔点：75 °C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowedH312 Harmful in contact with skinH360 May damage fertility or the unborn childH340 May cause genetic defectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P270,P362+P364,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317

Merck Index：1221

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装