产品名称

英文名称：Etoricoxib

同义词

Etoricoxib、202409-33-4、Arcoxia、Tauxib、Nucoxia、Algix、MK-0663、5-Chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-2,3'-bipyridine、MK-663、L-791456、MK 0663、2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-、5-chloro-6'-methyl-3-[4-(methylsulfonyl)p、MK-663、MK-0663、依托考昔、5-氯-6'-甲基-3-[4-(甲磺酰基)苯基]]-2,3'-联吡啶、5-氯-3-[4-(甲磺酰基)苯基]-2-(2-甲基-5-吡啶基)吡啶

产品性质

CAS编号：202409-33-4

分子式：C18H15ClN2O2S

分子量：358.84

Beilstein号：8073797

MDL号：MFCD06797512

PubChem编号：123619

别名：MK-663|MK-0663|依托考昔|5-氯-6'-甲基-3-[4-(甲磺酰基)苯基]]-2,3'-联吡啶|5-氯-3-[4-(甲磺酰基)苯基]-2-(2-甲基-5-吡啶基)吡啶

英文别名：Etoricoxib|202409-33-4|Arcoxia|Tauxib|Nucoxia|Algix|MK-0663|5-Chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-2,3'-bipyridine|MK-663|L-791456|MK 0663|2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-|5-chloro-6'-methyl-3-[4-(methylsulfonyl)p

规格或纯度：≥98.0%

英文名称：Etoricoxib

生化机理：Etoricoxib is a specific inhibitor of COX-2(Cyclooxygenase-2)

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：10mg售完停产，不再备货

产品介绍：Etoricoxib(MK-0663)能选择性抑制COX-2，IC50为1.1_mu_M（LPS诱导的前列腺素E2合成实验），而对COX-1的IC50则为116_mu_M（凝血后血清血栓素B2生成实验）。A specific inhibitor of COX-2.EtoricoxibEtoricoxib(MK-0663) selectively inhibited COX-2 in human whole blood assays in vitro, with an IC50 value of1.1 ± 0.1 μM for COX-2 (LPS-induced prostaglandin E2 synthesis), compared with an IC50 value of 116 ± 8 μM for COX-1 (serum thromboxane B2 generation after clotting of the blood). A specific inhibitor of COX-2.

ALogP：3.3

IUPAC Name：5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine

INCHI：InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3

InChi Key：MNJVRJDLRVPLFE-UHFFFAOYSA-N

Canonical SMILES：CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C

Isomeric SMILES：CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C

WGK Germany：3

PubChem CID：123619

Wikipedia：Etoricoxib

ChEMBL Ligand：CHEMBL416146

DrugBank Ligand：DB01628

CAS Registry No.：202409-33-4

ChEBI：CHEBI6339

RCSB PDB Ligand：5CH

PEP：etoricoxib

DrugCentral Ligand：1113

溶解性：Soluble in DMSO, and methanol

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH310 Fatal in contact with skin

预防措施声明：P280,P310,P302+P350

产品包装