产品名称

英文名称：Fluvastatin Sodium

同义词

FLUVASTATIN SODIUM、93957-55-2、Lescol、94061-80-0、Fluvastatin sodium salt、Vastin、(3R,5S)-Fluvastatin Sodium Salt、Fluvastatin (sodium)、Canef、Sri 62320、Sri-62320、Fluvastatin sodium (Lescol)、(3r,5s)-fluvastatin sodium、Sodium (3R,5S,E)-7-(3-(4-fluorophenyl)-1-i、氟伐他汀钠

产品性质

CAS编号：93957-55-2

分子式：C24H25FNNaO4

分子量：433.45

MDL号：MFCD08063391

PubChem编号：23663976

别名：氟伐他汀钠

英文别名：FLUVASTATIN SODIUM|93957-55-2|Lescol|94061-80-0|Fluvastatin sodium salt|Vastin|(3R,5S)-Fluvastatin Sodium Salt|Fluvastatin (sodium)|Canef|Sri 62320|Sri-62320|Fluvastatin sodium (Lescol)|(3r,5s)-fluvastatin sodium|Sodium (3R,5S,E)-7-(3-(4-fluorophenyl)-1-i

规格或纯度：≥98%

英文名称：Fluvastatin Sodium

生化机理：Fluvastatin, Sodium Salt is a synthetic inhibitor of HMGCR (HMG-CoA reductase) (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic compound and as an antioxidant. Fluvastatin also inhibits induction of the LDL receptor on HepG2 cells at a concentration of 0.1-1.0 μM. Research shows that fluvastatin can inhibit the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC50 = 12 μM).Competitive HMG-CoA reductase inhibitor (IC 50 = 40 - 100 nM in human and rat microsomes). Potent inhibitor of vascular smooth muscle cell proliferation in vitro (IC 50 = 70 nM).

应用：An inhibitor of HMGCR (HMG-CoA reductase).

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Fluvastatin Sodium抑制HMG-CoA reductase（HMG-CoA还原酶)活性，IC50为8 nM。An inhibitor of HMGCR (HMG-CoA reductase).Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM.An inhibitor of HMGCR (HMG-CoA reductase).

IUPAC Name：sodium;(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

INCHI：InChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m1./s1

InChi Key：ZGGHKIMDNBDHJB-NRFPMOEYSA-M

Canonical SMILES：CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]

Isomeric SMILES：CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]

RTECS：MJ9675100

PubChem CID：23663976

溶解性：Soluble in water (30 mg/ml), DMSO (100 mM), methanol, and ethanol (25 mM).

敏感性：易吸湿

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaledH351 Suspected of causing cancerH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH310 Fatal in contact with skinH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH350 May cause cancerH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P262,P361+P364,P203,P264+P265,P301+P316,P301+P317,P305+P354+P338,P318,P317,P337+P317,P332+P317,P316,P319

Merck Index：4218

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