产品名称

英文名称：Elvitegravir (GS-9137, JTK-303)

同义词

6-[(3-chloro-2-fluoro-phenyl)methyl]-1-[(1S)-1-(hydroxymethyl)-2-methyl-propyl]-7-methoxy-4-oxo-quinoline-3-carboxylic acid、6-(3-chloro-2-fluorobenzyl)-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid、BDBM50、埃替拉韦

产品性质

CAS编号：697761-98-1

分子式：C23H23ClFNO5

分子量：447.88

PubChem编号：5277135

别名：埃替拉韦

英文别名：6-[(3-chloro-2-fluoro-phenyl)methyl]-1-[(1S)-1-(hydroxymethyl)-2-methyl-propyl]-7-methoxy-4-oxo-quinoline-3-carboxylic acid|6-(3-chloro-2-fluorobenzyl)-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|BDBM50

规格或纯度：≥99%

英文名称：Elvitegravir (GS-9137, JTK-303)

生化机理：Elvitegravir is an inhibitor of HIV-1 integrase which is responsible for the strand-transfer step of integration. Studies indicate that Elvitegravir is effective against HIV-1 strains that are resistant to other agents such as nucleotide reverse-transcriptase inhibitors (NRTIs), nonnucleoside reverse-transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), as a result of Elvitegravir's ability to block the function of HIV1 integrase.Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC 50 = 0.7 nM), HIV 2 EHO (IC 50 = 2.8 nM)\xa0and HIV-2 ROD (IC 50 = 1.1 nM) in cell free assays.\xa0Elvitegravir blocks integration of HIV cDNA via inhibition of D

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Elvitegravir (GS-9137, JTK-303)是人免疫缺陷病毒整合酶抑制剂，作用于HIV-1 IIIB， HIV-2 EHO和HIV-2 ROD时，IC50分别为0.7，2.8和1.4 nM。An HIV-1 integrase inhibitorElvitegravir (GS-9137, JTK-303) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.An HIV-1 integrase inhibitor

ALogP：5.3

IUPAC Name：6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid

INCHI：InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1

InChi Key：JUZYLCPPVHEVSV-LJQANCHMSA-N

Canonical SMILES：CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O

Isomeric SMILES：CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O

PubChem CID：5277135

ChEMBL Ligand：CHEMBL204656

BindingDB Ligand：50183273

DrugBank Ligand：DB09101

CAS Registry No.：697761-98-1

RCSB PDB Ligand：ELV

溶解性：DMSO ≥86mg/mL Water <1.2mg/mL Ethanol ≥85mg/mL

危险声明：H412 Harmful to aquatic life with long lasting effects

预防措施声明：P273,P501

产品包装