产品名称

英文名称：Amuvatinib (MP-470)

同义词

Amuvatinib、850879-09-3、MP-470、MP470、MP 470、Amuvatinib (MP-470)、HPK56、HPK 56、HPK-56、N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide、N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperaz

产品性质

CAS编号：850879-09-3

分子式：C23H21N5O3S

分子量：447.52

PubChem编号：11282283

英文别名：Amuvatinib|850879-09-3|MP-470|MP470|MP 470|Amuvatinib (MP-470)|HPK56|HPK 56|HPK-56|N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide|N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperaz

规格或纯度：≥98%

英文名称：Amuvatinib (MP-470)

生化机理：Amuvatinib is a potent and multi-targeted tyrosine kinase inhibitor that inhibits c-Kit and PDGFα and has been shown to induce apoptosis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Amuvatinib (MP-470)是多靶点抑制剂，对c-Kit(D816H)，PDGFRα(V561D)和FLT3(D835Y)的IC50分别为10 nM，40 nM和81 nM。A multi-targeted tyrosine kinase inhibitor of PDGF and c-Kit。Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively.A multi-targeted tyrosine kinase inhibitor of PDGF and c-Kit。

ALogP：3.5

IUPAC Name：N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide

INCHI：InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32)

InChi Key：FOFDIMHVKGYHRU-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6

Isomeric SMILES：C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6

PubChem CID：11282283

CAS Registry No.：850879-09-3

ChEMBL Ligand：CHEMBL2103851

溶解性：DMSO 32 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装