产品名称

英文名称：Teriflunomide

同义词

J-010046、MFCD00910058、HY-110159、NCGC00263218-07、A771726、A-771726、A77-1726、A801897、SW219377-1、2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-、2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide、Aubagio、HMS3886K11、AC-521、IRINOTECAN H、特立氟胺

产品性质

CAS编号：163451-81-8

分子式：C12H9F3N2O2

分子量：270.21

MDL号：MFCD00910058

PubChem编号：54684141

别名：特立氟胺

英文别名：J-010046|MFCD00910058|HY-110159|NCGC00263218-07|A771726|A-771726|A77-1726|A801897|SW219377-1|2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-|2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide|Aubagio|HMS3886K11|AC-521|IRINOTECAN H

规格或纯度：≥99%

英文名称：Teriflunomide

生化机理：An active metabolite of leflunomide that inhibits Cox-2

储存温度：2-8°C储存

运输条件：冰袋运输

备注：250mg卖完停产，不再备货

产品介绍：A77 1726, also known as teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-κ B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thoμght to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound.A77 1726, also known as teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-κ B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thought to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound.

IUPAC Name：(Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide

INCHI：InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-

InChi Key：UTNUDOFZCWSZMS-YFHOEESVSA-N

Canonical SMILES：CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O

Isomeric SMILES：C/C(=C(\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O

WGK Germany：3

PubChem CID：54684141

溶解性：Soluble in DMSO (32 mg/ml at 25 °C), methanol, DMF (~21.6 mg/ml), ethanol (1.35 mg/ml, sonication), and water (slightly).

敏感性：对热敏感

熔点：229 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：9165

产品包装