产品名称

英文名称：Canagliflozin

同义词

JNJ 24831754ZAE、JNJ 28431754AAA、TA 7284、JNJ 28431754、(2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol、坎格列净、(2S,3R,4R,5S,6R)-2-(3-((5-(4-氟苯基)噻吩-2-基)甲基)-4-甲基苯基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇

产品性质

CAS编号：842133-18-0

分子式：C24H25FO5S

分子量：444.52

PubChem编号：24812758

别名：坎格列净|(2S,3R,4R,5S,6R)-2-(3-((5-(4-氟苯基)噻吩-2-基)甲基)-4-甲基苯基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇

英文别名：JNJ 24831754ZAE|JNJ 28431754AAA|TA 7284|JNJ 28431754|(2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

规格或纯度：≥98%

英文名称：Canagliflozin

生化机理：Canagliflozin(JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284) is an experimental drμg being developed by Johnson & Johnson for the treatment of type 2 diabetes.Canagliflozin(JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284) is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated throμgh the urine.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Canagliflozin (JNJ 28431754) 是一种选择性的 SGLT2 抑制剂，作用于表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO细胞，IC50 分别为 2 nM，3.7 nM 和 4.4 nM Canagliflozin inhibits Na+- dependent 14C-AMG uptake in a concentration-dependent fashion. It is a novel C-glucoside with thiophene ring.

IUPAC Name：(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

INCHI：InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1

InChi Key：XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

Canonical SMILES：CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F

Isomeric SMILES：CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F

PubChem CID：24812758

ChEMBL Ligand：CHEMBL2048484

CAS Registry No.：842133-18-0

DrugBank Ligand：DB08907

Wikipedia：Canagliflozin

PEP：canagliflozin

DrugCentral Ligand：4758

溶解性：DMSO 89 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH318 Causes serious eye damageH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P305+P351+P338,P273,P280,P405,P501,P264,P260,P270,P391,P330,P263,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P337+P317

产品包装