产品名称

英文名称：GSK3787

同义词

GSK3787、188591-46-0、GSK-3787、GSK 3787、4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide、4-chloro-N-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfonylethyl]benzamide、CHEMBL598608、DD8MJ95LTV、4-chloro-N-(2-((5-(trifluoromethyl)pyridin-2-yl)s

产品性质

CAS编号：188591-46-0

分子式：C15H12ClF3N2O3S

分子量：392.78

MDL号：MFCD00099612

PubChem编号：2800647

英文别名：GSK3787|188591-46-0|GSK-3787|GSK 3787|4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide|4-chloro-N-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfonylethyl]benzamide|CHEMBL598608|DD8MJ95LTV|4-chloro-N-(2-((5-(trifluoromethyl)pyridin-2-yl)s

规格或纯度：≥98%

英文名称：GSK3787

生化机理：GSK3787 is potent and selective PPAR beta/delta (Peroxisome Proliferator-Activated Receptor) antagonist (IC50 in PPAR ligand displacement assays = 200 nM against human PPARβ and >10 μM against PPARα or PPARγ). GSK3787 acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells.Potent, selective, irreversible peroxisome proliferator-activated receptor delta (PPARδ) antagonist (IC 50 = 130 nM). No affinity for PPARα or PPARγ. Orally active. Active in vivo and in vitro .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：GSK3787是不可逆的PPARδ选择性拮抗剂，pIC50为6.6，对hPPARα和hPPARγ无亲和力。A potent and selective peroxisome proliferatior-activated recepter δ antagonistGSK3787 is as a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ.A potent and selective peroxisome proliferatior-activated recepter δ antagonist

IUPAC Name：4-chloro-N-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfonylethyl]benzamide

INCHI：InChI=1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22)

InChi Key：JFUIMTGOQCQTPF-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1C(=O)NCCS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)Cl

Isomeric SMILES：C1=CC(=CC=C1C(=O)NCCS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)Cl

WGK Germany：3

PubChem CID：2800647

溶解性：DMSO 79 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.45

折光率：1.54

沸点：585.10 °C at 760 mmHg

熔点：217.94°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritation

预防措施声明：P305+P351+P338,P280,P264+P265,P337+P317

产品包装