产品名称

英文名称：TAK-901

同义词

TAK-901、934541-31-8、5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide、TAK901、TAK 901、5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide、DM9UIR23R7

产品性质

CAS编号：934541-31-8

分子式：C28H32N4O3S

分子量：504.66

PubChem编号：16124208

英文别名：TAK-901|934541-31-8|5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide|TAK901|TAK 901|5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide|DM9UIR23R7

规格或纯度：≥98%

英文名称：TAK-901

生化机理：TAK-901 is a potent and tight-binding Aurora B kinase inhibitor. TAK-901 targets multiple kinases in vitro, but appears to mainly target Aurora B in cells and in vivo. TAK-901 suppresses cellular histone H3 phosphorylation and induced polyploidy.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍TAK-901是多靶点的的极光激酶 (aurora)抑制剂，对极光激酶A和B的IC50 值分别为21 和15 nM。Product DescribtionTAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively.

ALogP：4.5

PubChem SID：488199045

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488199045

IUPAC Name：5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide

INCHI：InChI=1S/C28H32N4O3S/c1-5-36(34,35)21-8-6-7-19(14-21)23-15-22(28(33)30-20-9-11-32(4)12-10-20)18(3)26-25(23)24-13-17(2)16-29-27(24)31-26/h6-8,13-16,20H,5,9-12H2,1-4H3,(H,29,31)(H,30,33)

InChi Key：WKDACQVEJIVHMZ-UHFFFAOYSA-N

Canonical SMILES：CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C

Isomeric SMILES：CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=C(N3)N=CC(=C4)C)C)C(=O)NC5CCN(CC5)C

PubChem CID：16124208

溶解性：DMSO 2 mg/mL, clear (warmed)

产品包装